Rob Moore, the studio vice chairman, has stated that a sequel will be developed. The film’s lead actors are contractually obligated to return. In January 2010, Rhett Reese and Paul Wernick, the writers of Zombieland, were hired to write the script for the sequel. Stephen Sommers was originally going to return as director of the sequel, but as of January 2011, Sommers will not be returning to direct. Production on the film will begin in June and the film will likely be released in 2012, also seeing the return of Storm Shadow actor, Lee Byung-hun. On January 17, 2011, The Hollywood Reporter confirmed once again that Lee Byung-hun will reprise his role as Storm Shadow in the sequel. Channing Tatum and Ray Park are also returning to the film as Duke and Snake-Eyes, respectively. Rachel Nichols, the actress who played Scarlett in the first film, said via Twitter that most cast members will not be returning, except for the three aforementioned actors. Paramount Pictures announced that Jon Chu will direct the sequel. The film is scheduled to be released on August 10, 2012.

The G.I. Joe movie sequel was originally thought to be titled G.I. Joe: Cobra Strikes, which was later denied by screenwriter Rhett Reese. UK X Factor winner Shayne Ward, actors Danny Arroyo, Erryn Arkin and former WWE Wrestler Shad Gaspard have auditioned for new roles for the sequel. Joseph Gordon-Levitt confirmed in an interview that he will not be returning as “The Commander” in the sequel. On June 5, 2011, actor Stephen Martines was cast as Cross-Country. On June 6, 2011, actor Dwayne Johnson was cast as Roadblock.  Elodie Yung is in talks to join the cast in the film as Jinx. On June 27, 2011 actor D.J. Cotrona and rapper Rza were cast as Flint and Blind Master. On July 1, 2011, Adrianne Palicki was confirmed for the lead female role of Lady Jaye. It was also announced on July 8 that Irish actor Ray Stevenson would portray the villain Firefly in the film.